Email VimbAdmin / Roundcubemail

Hello can anyone help:

2019/02/13 12:45:13 [error] 19730#0: 434 connect() failed (111: Connection refused) while connecting to upstream, client: 000.0.000.000, server: webmail., request: “POST /?_task=mail&_action=refresh HTTP/1.1”, upstream: “fastcgi://127.0.0.1:8000”, host: “webmail.domain.tld”, referrer: “http://webmail.domain.tld/?_task=mail&_mbox=Sent

same error by ContactForm

2019/02/13 12:26:17 [error] 14859#0: *213 connect() failed (111: Connection refused) while connecting to upstream, client: 000.0.000.000, server: domain.tld, request: “GET /de/subdirectory/ HTTP/2.0”, upstream: “fastcgi://127.0.0.1:8000”, host: “domain.tld”

Thanks.